C-reactive protein to lymphocyte ratio is a significant predictive factor for poor short-term clinical outcomes of SARS-CoV-2 BA.2.2 patients

Benjie Xiao; Yinyan Wu; Huazheng Liang; Huazheng Liang; Jingjing Xiao; Yudi Han; Zhangwei Yang; Yong Bi; Yong Bi

doi:10.3389/fpubh.2023.1168375

Frontiers in Public Health (Apr 2023)

C-reactive protein to lymphocyte ratio is a significant predictive factor for poor short-term clinical outcomes of SARS-CoV-2 BA.2.2 patients

Benjie Xiao,
Yinyan Wu,
Huazheng Liang,
Huazheng Liang,
Jingjing Xiao,
Yudi Han,
Zhangwei Yang,
Yong Bi,
Yong Bi

Affiliations

Benjie Xiao: Department of Neurology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China
Yinyan Wu: Department of Neurology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China
Huazheng Liang: Clinical Research Center for Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Huazheng Liang: Monash Suzhou Research Institute, Suzhou, Jiangsu Province, China
Jingjing Xiao: Department of Neurology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China
Yudi Han: Department of Neurology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China
Zhangwei Yang: Department of Information, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China
Yong Bi: Shanghai University of Medicine & Health Sciences Affiliated Zhoupu hospital, Shanghai, China
Yong Bi: Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

DOI: https://doi.org/10.3389/fpubh.2023.1168375
Journal volume & issue: Vol. 11

Abstract

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ObjectiveThe aim of the present study is to assess the utility of C-reactive protein to Lymphocyte Ratio (CLR) in predicting short-term clinical outcomes of patients infected by SARS-CoV-2 BA.2.2.MethodsThis retrospective study was performed on 1,219 patients with laboratory-confirmed SARS-CoV-2 BA.2.2 to determine the association of CLR with short-term clinical outcomes. Independent Chi square test, Rank sum test, and binary logistic regression analysis were performed to calculate mean differences and adjusted odds ratios (aORs) with their 95% CI, respectively.ResultsOver 8% of patients admitted due to SARS-CoV-2 BA.2.2. were critically ill. The best cut-off value of CLR was 21.25 in the ROC with a sensitivity of 72.3% and a specificity of 86%. After adjusting age, gender, and comorbidities, binary logistic regression analysis showed that elevated CLR was an independent risk factor for poor short-term clinical outcomes of COVID-19 patients.ConclusionC-reactive protein to Lymphocyte Ratio is a significant predictive factor for poor short-term clinical outcomes of SARS-CoV-2 BA.2.2 inflicted patients.

Published in Frontiers in Public Health

ISSN: 2296-2565 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Public aspects of medicine
Website: https://www.frontiersin.org/journals/public-health

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