Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer

Hyun Goo Woo; Ji-Hye Choi; Sarah Yoon; Byul A. Jee; Eun Ju Cho; Jeong-Hoon Lee; Su Jong Yu; Jung-Hwan Yoon; Nam-Joon Yi; Kwang-Woong Lee; Kyung-Suk Suh; Yoon Jun Kim

doi:10.1038/s41467-017-00991-w

Nature Communications (Oct 2017)

Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer

Hyun Goo Woo,
Ji-Hye Choi,
Sarah Yoon,
Byul A. Jee,
Eun Ju Cho,
Jeong-Hoon Lee,
Su Jong Yu,
Jung-Hwan Yoon,
Nam-Joon Yi,
Kwang-Woong Lee,
Kyung-Suk Suh,
Yoon Jun Kim

Affiliations

Hyun Goo Woo: Department of Physiology, Ajou University School of Medicine
Ji-Hye Choi: Department of Physiology, Ajou University School of Medicine
Sarah Yoon: Department of Physiology, Ajou University School of Medicine
Byul A. Jee: Department of Physiology, Ajou University School of Medicine
Eun Ju Cho: Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine
Jeong-Hoon Lee: Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine
Su Jong Yu: Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine
Jung-Hwan Yoon: Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine
Nam-Joon Yi: Department of Surgery, Seoul National University College of Medicine
Kwang-Woong Lee: Department of Surgery, Seoul National University College of Medicine
Kyung-Suk Suh: Department of Surgery, Seoul National University College of Medicine
Yoon Jun Kim: Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine

DOI: https://doi.org/10.1038/s41467-017-00991-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Hepatocellular carcinoma is known to harbour numerous genomic and epigenomic aberrations, driving transcriptomic deregulation. Here, the authors integrate genomic, epigenomic, and expression data to reveal three prognostic subtypes, providing insight to the pathobiology of hepatocellular carcinoma.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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