Study of the mechanisms cardioprotektive effect of 3-(2,2,2- trimethylhydrazinium) propionate

Abstract

The work evaluated the influence of 3-(2,2,2-trimethylhydrazinium) propionate per square necrotic myocardium of the left ventricle and the level troponina I serum during acute coronary occlusion (60 minutes) followed by reperfusion (90 min) in anesthetized rabbits. It is shown that distant and pharmacological preconditioning 3 (2,2,2-trimethylhydrazinium) propionate reduce nekrooza zone 3 and 1.5 times, respectively. Found participation ATP dependent potassium channels (KATF channels) of endothelial and inducible NO-synthase in the implementation of the cytoprotective effect of distant preconditioning and 3-(2,2,2-trimethylhydrazinium) propionate, indicating that the implementation of the mechanism of pharmacological preconditioning in his kardioprotektvnom action.

Keywords

• прекондиционирование
• ишемия/реперфузия
• 3-(2
• 2
• 2-триметилгидразиний) пропионат
• preconditioning
• ischemia/reperfusion
• 3-(2
• 2
• 2-trimethylhydrazinium) propionate