SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation

Lingjie Yan; Tao Zhang; Kai Wang; Zezhao Chen; Yuanxin Yang; Bing Shan; Qi Sun; Mengmeng Zhang; Yichi Zhang; Yedan Zhong; Nan Liu; Jinyang Gu; Daichao Xu

doi:10.1038/s41467-022-34993-0

Nature Communications (Nov 2022)

SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation

Lingjie Yan,
Tao Zhang,
Kai Wang,
Zezhao Chen,
Yuanxin Yang,
Bing Shan,
Qi Sun,
Mengmeng Zhang,
Yichi Zhang,
Yedan Zhong,
Nan Liu,
Jinyang Gu,
Daichao Xu

Affiliations

Lingjie Yan: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Tao Zhang: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Kai Wang: Department of Hepatobiliary and Pancreatic Surgery, Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou First People’s Hospital Affiliated Zhejiang University School of Medicine
Zezhao Chen: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yuanxin Yang: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Bing Shan: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Qi Sun: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Mengmeng Zhang: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yichi Zhang: Department of Transplantation, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Yedan Zhong: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Nan Liu: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Jinyang Gu: Department of Transplantation, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Daichao Xu: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-34993-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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The receptor-interacting protein (RIPK1) promotes cell death and contributes to nonalcoholic steatohepatitis pathogenesis. Here the authors report that a SUMO-specific protease, SENP1, deSUMOylates RIPK1 and inhibits cell death in a mouse model of non-alcoholic fatty liver disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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