Nature Communications (Aug 2020)
T-cells produce acidic niches in lymph nodes to suppress their own effector functions
- Hao Wu,
- Veronica Estrella,
- Matthew Beatty,
- Dominique Abrahams,
- Asmaa El-Kenawi,
- Shonagh Russell,
- Arig Ibrahim-Hashim,
- Dario Livio Longo,
- Yana K. Reshetnyak,
- Anna Moshnikova,
- Oleg A. Andreev,
- Kimberly Luddy,
- Mehdi Damaghi,
- Krithika Kodumudi,
- Smitha R. Pillai,
- Pedro Enriquez-Navas,
- Shari Pilon-Thomas,
- Pawel Swietach,
- Robert J. Gillies
Affiliations
- Hao Wu
- Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute
- Veronica Estrella
- Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute
- Matthew Beatty
- Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute
- Dominique Abrahams
- Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute
- Asmaa El-Kenawi
- Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute
- Shonagh Russell
- Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute
- Arig Ibrahim-Hashim
- Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute
- Dario Livio Longo
- Institute of Biostructures and Bioimaging (IBB), National Research Council of Italy (CNR)
- Yana K. Reshetnyak
- Department of Physics, University of Rhode Island
- Anna Moshnikova
- Department of Physics, University of Rhode Island
- Oleg A. Andreev
- Department of Physics, University of Rhode Island
- Kimberly Luddy
- Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute
- Mehdi Damaghi
- Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute
- Krithika Kodumudi
- Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute
- Smitha R. Pillai
- Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute
- Pedro Enriquez-Navas
- Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute
- Shari Pilon-Thomas
- Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute
- Pawel Swietach
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Robert J. Gillies
- Department of Cancer Physiology, H. Lee Moffitt Cancer Center and Research Institute
- DOI
- https://doi.org/10.1038/s41467-020-17756-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
T-cell activation primarily occurs in the lymph nodes, highly organized and specialized secondary lymphoid organs. Here the authors show that the acidic extracellular pH in lymph node paracortical zones limits cytokine production by effector T-cells, but does not alter their activation by antigen-presenting cells.
