Nature Communications (Feb 2018)

Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor

  • David L. Gray,
  • John A. Allen,
  • Scot Mente,
  • Rebecca E. O’Connor,
  • George J. DeMarco,
  • Ivan Efremov,
  • Patrick Tierney,
  • Dmitri Volfson,
  • Jennifer Davoren,
  • Edward Guilmette,
  • Michelle Salafia,
  • Rouba Kozak,
  • Michael D. Ehlers

DOI
https://doi.org/10.1038/s41467-017-02776-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

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Dopamine receptor agonists are used for the treatment of various psychiatric diseases. Here, the authors screen approximately three million compounds and identify a novel class of D1R agonists that do not have a catechol scaffold and possess promising pharmacokinetic properties.