Nature Communications (Feb 2023)
Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus
- Naijun Miao,
- Zhuning Wang,
- Qinlan Wang,
- Hongyan Xie,
- Ninghao Yang,
- Yanzhe Wang,
- Jin Wang,
- Haixia Kang,
- Wenjuan Bai,
- Yuanyuan Wang,
- Rui He,
- Kepeng Yan,
- Yang Wang,
- Qiongyi Hu,
- Zhaoyuan Liu,
- Fubin Li,
- Feng Wang,
- Florent Ginhoux,
- Xiaoling Zhang,
- Jianyong Yin,
- Limin Lu,
- Jing Wang
Affiliations
- Naijun Miao
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Zhuning Wang
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Qinlan Wang
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Hongyan Xie
- Department of Physiology and Pathophysiology, School of Basic Medicine Sciences, Fudan University
- Ninghao Yang
- Department of Physiology and Pathophysiology, School of Basic Medicine Sciences, Fudan University
- Yanzhe Wang
- Department of Nephrology, Shanghai Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine
- Jin Wang
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Haixia Kang
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Wenjuan Bai
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Yuanyuan Wang
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Rui He
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Kepeng Yan
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Yang Wang
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Qiongyi Hu
- Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Zhaoyuan Liu
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Fubin Li
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Feng Wang
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- Florent Ginhoux
- Singapore Immunology Network, Agency for Science, Technology and Research
- Xiaoling Zhang
- Department of Orthopedic Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Jianyong Yin
- Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Limin Lu
- Department of Physiology and Pathophysiology, School of Basic Medicine Sciences, Fudan University
- Jing Wang
- Center for Immune-related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-36522-z
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 20
Abstract
Systemic lupus erythematosus is characterised by the generation of antibodies targeting DNA and nuclear antigens. Here, the authors show that oxidised mitochondrial DNA induces gasdermin D oligomerization and promotes pore formation in neutrophils from patients with SLE.
