Nature Communications (Nov 2018)
Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
- Youngmin A. Lee,
- Luke A. Noon,
- Kemal M. Akat,
- Maria D. Ybanez,
- Ting-Fang Lee,
- Marie-Luise Berres,
- Naoto Fujiwara,
- Nicolas Goossens,
- Hsin-I Chou,
- Fatemeh P. Parvin-Nejad,
- Bilon Khambu,
- Elisabeth G. M. Kramer,
- Ronald Gordon,
- Cathie Pfleger,
- Doris Germain,
- Gareth R. John,
- Kirk N. Campbell,
- Zhenyu Yue,
- Xiao-Ming Yin,
- Ana Maria Cuervo,
- Mark J. Czaja,
- M. Isabel Fiel,
- Yujin Hoshida,
- Scott L. Friedman
Affiliations
- Youngmin A. Lee
- Division of Liver Diseases, Icahn School of Medicine at Mount Sinai
- Luke A. Noon
- Division of Liver Diseases, Icahn School of Medicine at Mount Sinai
- Kemal M. Akat
- Laboratory of RNA Molecular Biology, Rockefeller University
- Maria D. Ybanez
- Division of Liver Diseases, Icahn School of Medicine at Mount Sinai
- Ting-Fang Lee
- Division of Liver Diseases, Icahn School of Medicine at Mount Sinai
- Marie-Luise Berres
- Department of Internal Medicine III, University Hospital RWTH Aachen
- Naoto Fujiwara
- Division of Liver Diseases, Icahn School of Medicine at Mount Sinai
- Nicolas Goossens
- Division of Liver Diseases, Icahn School of Medicine at Mount Sinai
- Hsin-I Chou
- Division of Liver Diseases, Icahn School of Medicine at Mount Sinai
- Fatemeh P. Parvin-Nejad
- Division of Liver Diseases, Icahn School of Medicine at Mount Sinai
- Bilon Khambu
- Department of Pathology & Laboratory Medicine, Indiana University School of Medicine
- Elisabeth G. M. Kramer
- Department of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Ronald Gordon
- Department for Pathology, Icahn School of Medicine at Mount Sinai
- Cathie Pfleger
- Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
- Doris Germain
- Department of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai
- Gareth R. John
- Department of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Kirk N. Campbell
- Division of Nephrology, Icahn School of Medicine at Mount Sinai
- Zhenyu Yue
- Department of Neurology, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
- Xiao-Ming Yin
- Department of Pathology & Laboratory Medicine, Indiana University School of Medicine
- Ana Maria Cuervo
- Department of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine
- Mark J. Czaja
- Department of Medicine, Emory University School of Medicine
- M. Isabel Fiel
- Department for Pathology, Icahn School of Medicine at Mount Sinai
- Yujin Hoshida
- Division of Liver Diseases, Icahn School of Medicine at Mount Sinai
- Scott L. Friedman
- Division of Liver Diseases, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-018-07338-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Increased levels of the Yap oncoprotein stimulate liver growth and promote hepatocarcinogenesis. Here the authors show that hepatocyte-specific loss of Atg7 in mice leads to decreased autophagic degradation of Yap and liver overgrowth, and further establish this association in human liver cancer tissues.
