Yacton and mexicor influence on prooxidant-antioxidant homeostasis and protein synthesis in the myocardium of rats in conditions of doxorubicin cardiomyopathy

Abstract

Doxorubicin, which is included in the scheme of cancer treatment, possesses cardiotoxicity that requires effective cardioprotectors searching. Aim. The aim of the study was to compare the influence of yacton and mexicor on the antioxidant system, oxidative modification of proteins, protein synthesis in the myocardium of rats in conditions of doxorubicin cardiomyopathy. Methods and results. The content of prooxidant-antioxidant homeostasis indicators - SOD, GPR, GR, AFG, KFG and proteinsynthesis – the protein content in the cytoplasma and mitochondria and protective effect of derivatives of succinic acid (yacton, mexicor) were studied in the myocardium of rats in the conditions doxorubicin cardiomyopathy with wellknown methods. Conclusion. It is stated that yakton similar to mexicor has protective influence on the prooxidant-antioxidant homeostasis, protein synthesis in the rats myocardium in conditions of doxorubicin cardiomyopathy.

Keywords

• Yacton
• Mexicor
• Homeostasis
• Proteins