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Disease Models & Mechanisms
(Dec 2022)
Sterol dysregulation in Smith–Lemli–Opitz syndrome causes astrocyte immune reactivity through microglia crosstalk
Bethany A. Freel,
Benjamin A. Kelvington,
Sonali Sengupta,
Malini Mukherjee,
Kevin R. Francis
Affiliations
Bethany A. Freel
Basic Biomedical Sciences, University of South Dakota, Vermillion, SD 57069, USA
Benjamin A. Kelvington
Cellular Therapies and Stem Cell Biology Group, Sanford Research, Sioux Falls, SD 57104, USA
Sonali Sengupta
Cellular Therapies and Stem Cell Biology Group, Sanford Research, Sioux Falls, SD 57104, USA
Malini Mukherjee
Functional Genomics and Bioinformatics Core, Sanford Research, Sioux Falls, SD 57104, USA
Kevin R. Francis
Cellular Therapies and Stem Cell Biology Group, Sanford Research, Sioux Falls, SD 57104, USA
DOI
https://doi.org/10.1242/dmm.049843
Journal volume & issue
Vol. 15, no. 12
Abstract
Read online
No abstracts available.
Keywords
cholesterol
astrocyte
dhcr7
reactivity
microglia
smith–lemli–opitz syndrome
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