Nature Communications (May 2018)

Silicon-oriented regio- and enantioselective rhodium-catalyzed hydroformylation

  • Cai You,
  • Xiuxiu Li,
  • Yuhong Yang,
  • Yu-Sheng Yang,
  • Xuefeng Tan,
  • Shuailong Li,
  • Biao Wei,
  • Hui Lv,
  • Lung-Wa Chung,
  • Xumu Zhang

DOI
https://doi.org/10.1038/s41467-018-04277-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Hydroformylation of 1,2-disubstituted alkenes usually occurs at the α position of the directing heteroatom. Here, the authors report the asymmetric rhodium-catalyzed hydroformylation of 1,2-disubstituted alkenylsilanes with excellent regioselectivity at the β position (relative to the silicon heteroatom) and enantioselectivity.