Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish

I. Castanon; J. T. Hannich; L. Abrami; F. Huber; M. Dubois; M. Müller; F. G. van der Goot; M. Gonzalez-Gaitan

doi:10.1038/s41467-020-17196-3

Nature Communications (Jul 2020)

Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish

I. Castanon,
J. T. Hannich,
L. Abrami,
F. Huber,
M. Dubois,
M. Müller,
F. G. van der Goot,
M. Gonzalez-Gaitan

Affiliations

I. Castanon: Department of Biochemistry and NCCR Chemical Biology, 30 Quai Ernest-Ansermet
J. T. Hannich: Department of Biochemistry and NCCR Chemical Biology, 30 Quai Ernest-Ansermet
L. Abrami: Global Health Institute, EPFL, Station 15
F. Huber: Vital-IT, SIB Swiss Institute of Bioinformatics
M. Dubois: Department of Biochemistry and NCCR Chemical Biology, 30 Quai Ernest-Ansermet
M. Müller: Vital-IT, SIB Swiss Institute of Bioinformatics
F. G. van der Goot: Global Health Institute, EPFL, Station 15
M. Gonzalez-Gaitan: Department of Biochemistry and NCCR Chemical Biology, 30 Quai Ernest-Ansermet

DOI: https://doi.org/10.1038/s41467-020-17196-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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During development, oriented cell division is important to proper body axis extension. Here, the authors show that sphingolipids are required to direct spindle rotation and oriented mitosis via Anthrax receptor palmitoylation in zebrafish gastrulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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