Rhinocerebral mucormycosis and treatment: Report of two cases

Abstract

Background and Aims: Rhinocerebral mucormycosis is an aggressive fungal disease that involves the nose, par nasal sinuses, orbit and central nervous system. It may rapidly be fatal. The major route of infection is inhalation. This infection usually occurs secondary to immune suppression, diabetic ketoacidosis, and prolonged use of antibiotics, steroids, etc.Case report: We presented two cases of rhino cerebral mucormycosis with same presentation. Both patients had underlying disease (diabetes or immune deficiency). The symptoms began including colds and sinusitis and was accompanied by pain and swelling in face. Smear of necrotic tissue showed branching nonseptated mycelium in favor of mucosal. These patients were treated Included Medical therapy with amphotericin-B and surgical treatment was undertaken to drain the sinuses.Conclusions: The diagnosis of rhino cerebral mucormycosis should be considered in the hospital in diabetic patients. Early diagnosis and treatment, treatment of the underlying disease are crucial factors leading to a good outcome.*Corresponding author: Graduate of Nursing, Faculty Member of Neyshabur University of Medical Sciences, Khorasan razavi, Iran.Email: [email protected]

Keywords

• Mucormycosis
• Rhinocerebral
• Amphotericin-B
• Underlying disease
• Diabetes