Communications Biology (Jun 2022)
Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers
- Ben Horst,
- Shrikant Pradhan,
- Roohi Chaudhary,
- Eduardo Listik,
- Liz Quintero-Macias,
- Alex Seok Choi,
- Michael Southard,
- Yingmiao Liu,
- Regina Whitaker,
- Nadine Hempel,
- Andrew Berchuck,
- Andrew B. Nixon,
- Nam Y. Lee,
- Yoav I. Henis,
- Karthikeyan Mythreye
Affiliations
- Ben Horst
- Department of Pathology and O’Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham
- Shrikant Pradhan
- Department of Chemistry and Biochemistry, University of South Carolina
- Roohi Chaudhary
- School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences
- Eduardo Listik
- Department of Pathology and O’Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham
- Liz Quintero-Macias
- Department of Pathology and O’Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham
- Alex Seok Choi
- Department of Pathology and O’Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham
- Michael Southard
- Department of Chemistry and Biochemistry, University of South Carolina
- Yingmiao Liu
- Department of Medicine and Duke Cancer Institute, Duke University Medical Center
- Regina Whitaker
- Department of Obstetrics and Gynecology, Duke University Medical Center, Durham NC, Duke University
- Nadine Hempel
- Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh
- Andrew Berchuck
- Department of Obstetrics and Gynecology, Duke University Medical Center, Durham NC, Duke University
- Andrew B. Nixon
- Department of Medicine and Duke Cancer Institute, Duke University Medical Center
- Nam Y. Lee
- Division of Pharmacology, Chemistry and Biochemistry, College of Medicine, University of Arizona
- Yoav I. Henis
- School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences
- Karthikeyan Mythreye
- Department of Pathology and O’Neal Comprehensive Cancer Center, Heersink School of Medicine, University of Alabama at Birmingham
- DOI
- https://doi.org/10.1038/s42003-022-03495-6
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 20
Abstract
Hypoxia increases levels of the heteromeric TGFβ ligand inhibin in ovarian cancer and inhibin promotes tumor growth, endothelial cell invasion and permeability.
