Nature Communications (Feb 2019)
Suppression of autophagic activity by Rubicon is a signature of aging
- Shuhei Nakamura,
- Masaki Oba,
- Mari Suzuki,
- Atsushi Takahashi,
- Tadashi Yamamuro,
- Mari Fujiwara,
- Kensuke Ikenaka,
- Satoshi Minami,
- Namine Tabata,
- Kenichi Yamamoto,
- Sayaka Kubo,
- Ayaka Tokumura,
- Kanako Akamatsu,
- Yumi Miyazaki,
- Tsuyoshi Kawabata,
- Maho Hamasaki,
- Koji Fukui,
- Kazunori Sango,
- Yoshihisa Watanabe,
- Yoshitsugu Takabatake,
- Tomoya S. Kitajima,
- Yukinori Okada,
- Hideki Mochizuki,
- Yoshitaka Isaka,
- Adam Antebi,
- Tamotsu Yoshimori
Affiliations
- Shuhei Nakamura
- Department of Genetics, Graduate School of Medicine, Osaka University
- Masaki Oba
- Diabetic Neuropathy Project, Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Setagaya
- Mari Suzuki
- Diabetic Neuropathy Project, Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Setagaya
- Atsushi Takahashi
- Department of Nephrology, Graduate School of Medicine, Osaka University
- Tadashi Yamamuro
- Department of Genetics, Graduate School of Medicine, Osaka University
- Mari Fujiwara
- Department of Genetics, Graduate School of Medicine, Osaka University
- Kensuke Ikenaka
- Department of Neurology, Graduate School of Medicine, Osaka University
- Satoshi Minami
- Department of Nephrology, Graduate School of Medicine, Osaka University
- Namine Tabata
- Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)
- Kenichi Yamamoto
- Department of Statistical Genetics, Graduate School of Medicine, Osaka University
- Sayaka Kubo
- Department of Genetics, Graduate School of Medicine, Osaka University
- Ayaka Tokumura
- Department of Genetics, Graduate School of Medicine, Osaka University
- Kanako Akamatsu
- Department of Genetics, Graduate School of Medicine, Osaka University
- Yumi Miyazaki
- Department of Genetics, Graduate School of Medicine, Osaka University
- Tsuyoshi Kawabata
- Department of Genetics, Graduate School of Medicine, Osaka University
- Maho Hamasaki
- Department of Genetics, Graduate School of Medicine, Osaka University
- Koji Fukui
- Department of Bioscience and Engineering, Shibaura Institute of Technology
- Kazunori Sango
- Diabetic Neuropathy Project, Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Setagaya
- Yoshihisa Watanabe
- Department of Basic Geriatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
- Yoshitsugu Takabatake
- Institute for Advanced Co-Creation Studies, Osaka University
- Tomoya S. Kitajima
- Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR)
- Yukinori Okada
- Department of Statistical Genetics, Graduate School of Medicine, Osaka University
- Hideki Mochizuki
- Department of Neurology, Graduate School of Medicine, Osaka University
- Yoshitaka Isaka
- Department of Nephrology, Graduate School of Medicine, Osaka University
- Adam Antebi
- Department of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing
- Tamotsu Yoshimori
- Department of Genetics, Graduate School of Medicine, Osaka University
- DOI
- https://doi.org/10.1038/s41467-019-08729-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Autophagic activity decreases with age via unknown mechanisms. Here the authors show that expression of the negative autophagy regulator Rubicon increases with age, that its genetic ablation improves lifespan and ameliorates a number of age-associated phenotypes in invertebrates and in mouse models.
