Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment

Claudia M. Wunderlich; P. Justus Ackermann; Anna Lena Ostermann; Petra Adams-Quack; Merly C. Vogt; My-Ly Tran; Alexei Nikolajev; Ari Waisman; Christoph Garbers; Sebastian Theurich; Jan Mauer; Nadine Hövelmeyer; F. Thomas Wunderlich

doi:10.1038/s41467-018-03773-0

Nature Communications (Apr 2018)

Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment

Claudia M. Wunderlich,
P. Justus Ackermann,
Anna Lena Ostermann,
Petra Adams-Quack,
Merly C. Vogt,
My-Ly Tran,
Alexei Nikolajev,
Ari Waisman,
Christoph Garbers,
Sebastian Theurich,
Jan Mauer,
Nadine Hövelmeyer,
F. Thomas Wunderlich

Affiliations

Claudia M. Wunderlich: Max Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne
P. Justus Ackermann: Max Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne
Anna Lena Ostermann: Max Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne
Petra Adams-Quack: Institute for Molecular Medicine, University Hospital Mainz
Merly C. Vogt: Max Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne
My-Ly Tran: Max Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne
Alexei Nikolajev: Institute for Molecular Medicine, University Hospital Mainz
Ari Waisman: Institute for Molecular Medicine, University Hospital Mainz
Christoph Garbers: Department of Biochemistry, Kiel University, Medical Faculty
Sebastian Theurich: Max Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne
Jan Mauer: Department of Pharmacology, Weill Cornell Medical College, Cornell University
Nadine Hövelmeyer: Institute for Molecular Medicine, University Hospital Mainz
F. Thomas Wunderlich: Max Planck Institute for Metabolism Research Cologne, Institute for Genetics, University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne

DOI: https://doi.org/10.1038/s41467-018-03773-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Inflammation can be induced by obesity, and has been linked with onset of colorectal cancer (CAC). Here the authors show in mouse models that obesity-induced interleukin-6 alters macrophage function to enhance CCL-20/CCR-6-mediated recruitment of B cells and γδ T cells, thereby promoting gut inflammation and CAC progression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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