TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment

• Yosuke Togashi,
• Hiroyoshi Nishikawa,
• Yutaka Suzuki,
• Yasuhiro Nakamura,
• Tomonori Kawasaki,
• Yuzuru Ikehara,
• Shusuke Kawashima,
• Takashi Inozume,
• Masahito Kawazu,
• Toshihide Ueno,
• Joji Nagasaki,
• Etsuko Tanji,
• Akiko Honobe,
• Takehiro Ohnuma,
• Tatsuyoshi Kawamura,
• Yoshiyasu Umeda,
• Yukiko Kiniwa,
• Osamu Yamasaki,
• Satoshi Fukushima,
• Hiroyuki Mano,
• Hiroyuki Matsue

Affiliations

Yosuke Togashi

Research Institute, Chiba Cancer Center, Chiba, Japan

Hiroyoshi Nishikawa

Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Chuo-ku/Kashiwa, Japan

Yutaka Suzuki

Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan

Yasuhiro Nakamura

Department of Skin Oncology/Dermatology, Saitama Medical University International Medical Center, Hidaka, Japan

Tomonori Kawasaki

Department of Pathology, Saitama Medical University International Medical Center, Hidaka, Japan

Yuzuru Ikehara

Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, Chiba, Japan

Shusuke Kawashima

Research Institute, Chiba Cancer Center, Chiba, Japan

Takashi Inozume

Research Institute, Chiba Cancer Center, Chiba, Japan

Masahito Kawazu

Research Institute, Chiba Cancer Center, Chiba, Japan

Toshihide Ueno

Division of Cellular Signaling, National Cancer Center Research Institute, Chuo-ku, Japan

Joji Nagasaki

Research Institute, Chiba Cancer Center, Chiba, Japan

Etsuko Tanji

Research Institute, Chiba Cancer Center, Chiba, Japan

Akiko Honobe

Department of Dermatology, University of Yamanashi, Chuo, Japan

Takehiro Ohnuma

Department of Dermatology, University of Yamanashi, Chuo, Japan

Tatsuyoshi Kawamura

Department of Dermatology, University of Yamanashi, Chuo, Japan

Yoshiyasu Umeda

Department of Skin Oncology/Dermatology, Saitama Medical University International Medical Center, Hidaka, Japan

Yukiko Kiniwa

Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan

Osamu Yamasaki

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

Satoshi Fukushima

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

Hiroyuki Mano

Division of Cellular Signaling, National Cancer Center Research Institute, Chuo-ku, Japan

Hiroyuki Matsue

Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan