Nature Communications (Mar 2020)
Analysis of DNA methylation associates the cystine–glutamate antiporter SLC7A11 with risk of Parkinson’s disease
- Costanza L. Vallerga,
- Futao Zhang,
- Javed Fowdar,
- Allan F. McRae,
- Ting Qi,
- Marta F. Nabais,
- Qian Zhang,
- Irfahan Kassam,
- Anjali K. Henders,
- Leanne Wallace,
- Grant Montgomery,
- Yu-Hsuan Chuang,
- Steve Horvath,
- Beate Ritz,
- Glenda Halliday,
- Ian Hickie,
- John B. Kwok,
- John Pearson,
- Toni Pitcher,
- Martin Kennedy,
- Steven R. Bentley,
- Peter A. Silburn,
- Jian Yang,
- Naomi R. Wray,
- Simon J. G. Lewis,
- Tim Anderson,
- John Dalrymple-Alford,
- George D. Mellick,
- Peter M. Visscher,
- Jacob Gratten
Affiliations
- Costanza L. Vallerga
- Institute for Molecular Bioscience, The University of Queensland
- Futao Zhang
- Institute for Molecular Bioscience, The University of Queensland
- Javed Fowdar
- Griffith Institute for Drug Discovery (GRIDD), Griffith University
- Allan F. McRae
- Institute for Molecular Bioscience, The University of Queensland
- Ting Qi
- Institute for Molecular Bioscience, The University of Queensland
- Marta F. Nabais
- Institute for Molecular Bioscience, The University of Queensland
- Qian Zhang
- Institute for Molecular Bioscience, The University of Queensland
- Irfahan Kassam
- Institute for Molecular Bioscience, The University of Queensland
- Anjali K. Henders
- Institute for Molecular Bioscience, The University of Queensland
- Leanne Wallace
- Institute for Molecular Bioscience, The University of Queensland
- Grant Montgomery
- Institute for Molecular Bioscience, The University of Queensland
- Yu-Hsuan Chuang
- Department of Epidemiology, Fielding School of Public Health, UCLA
- Steve Horvath
- Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles (UCLA)
- Beate Ritz
- Department of Epidemiology, Fielding School of Public Health, UCLA
- Glenda Halliday
- Brain and Mind Centre & Faculty of Medicine and Health, The University of Sydney
- Ian Hickie
- Brain and Mind Centre & Faculty of Medicine and Health, The University of Sydney
- John B. Kwok
- Brain and Mind Centre & Faculty of Medicine and Health, The University of Sydney
- John Pearson
- Department of Pathology, University of Otago
- Toni Pitcher
- New Zealand Brain Research Institute
- Martin Kennedy
- Department of Pathology, University of Otago
- Steven R. Bentley
- Griffith Institute for Drug Discovery (GRIDD), Griffith University
- Peter A. Silburn
- Queensland Brain Institute, The University of Queensland
- Jian Yang
- Institute for Molecular Bioscience, The University of Queensland
- Naomi R. Wray
- Institute for Molecular Bioscience, The University of Queensland
- Simon J. G. Lewis
- Brain and Mind Centre & Faculty of Medicine and Health, The University of Sydney
- Tim Anderson
- New Zealand Brain Research Institute
- John Dalrymple-Alford
- New Zealand Brain Research Institute
- George D. Mellick
- Griffith Institute for Drug Discovery (GRIDD), Griffith University
- Peter M. Visscher
- Institute for Molecular Bioscience, The University of Queensland
- Jacob Gratten
- Institute for Molecular Bioscience, The University of Queensland
- DOI
- https://doi.org/10.1038/s41467-020-15065-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
Parkinson’s disease (PD) is a common neurodegenerative disorder with a complex etiology involving genetics and the environment. Here, Vallerga et al. identify two CpG probes associated with PD in a blood cell type-corrected epigenome-wide meta-analysis, implicating the SLC7A11 gene as a plausible biological target.
