mBio (Jun 2021)

VIP-SPOT: an Innovative Assay To Quantify the Productive HIV-1 Reservoir in the Monitoring of Cure Strategies

  • Maria C. Puertas,
  • Ángel Bayón-Gil,
  • Maria C. Garcia-Guerrero,
  • Maria Salgado,
  • Víctor Urrea,
  • Sara Morón-López,
  • Ruth Peña,
  • Esther Jiménez-Moyano,
  • Bonaventura Clotet,
  • Julia G. Prado,
  • Javier Martinez-Picado

DOI
https://doi.org/10.1128/mBio.00560-21
Journal volume & issue
Vol. 12, no. 3

Abstract

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Current efforts aimed at finding a definitive cure for HIV-1 infection are hampered mainly by the persistence of a viral reservoir in latently infected cells. While complete viral eradication from the body remains elusive, finding a functional cure to enable control of viremia without the need for continuous treatment is a key goal.