Folia Veterinaria (Mar 2018)

The Role of Meningococcal Porin B in Protein-Protein Interactions with Host Cells

  • Káňová E.,
  • Jiménez-Munguía I.,
  • Čomor Ľ.,
  • Tkáčová Z.,
  • Širochmanová I.,
  • Bhide K.,
  • Bhide M.

DOI
https://doi.org/10.2478/fv-2018-0008
Journal volume & issue
Vol. 62, no. 1
pp. 52 – 58

Abstract

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Neisseria meningitidis is a Gram-negative diplococcus responsible for bacterial meningitis and fatal sepsis. Ligand-receptor interactions are one of the main steps in the development of neuroinvasion. Porin B (PorB), neisserial outer membrane protein (ligand), binds to host receptors and triggers many cell signalling cascades allowing the meningococcus to damage the host cells or induce immune cells responses via the TLR2-dependent mechanisms. In this paper, we present a brief review of the structure and function of PorB.

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