Nature Communications (Jun 2022)

DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II

  • Barbara Steurer,
  • Roel C. Janssens,
  • Marit E. Geijer,
  • Fernando Aprile-Garcia,
  • Bart Geverts,
  • Arjan F. Theil,
  • Barbara Hummel,
  • Martin E. van Royen,
  • Bastiaan Evers,
  • René Bernards,
  • Adriaan B. Houtsmuller,
  • Ritwick Sawarkar,
  • Jurgen Marteijn

DOI
https://doi.org/10.1038/s41467-022-31329-w
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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DNA damage inhibits elongating RNA polymerase II, but also initiates genome-wide transcriptional responses. Here the authors reveal that particularly promoter-bound Pol II is degraded upon DNA damage in a GSK3 signaling-mediated response.