Nature Communications (Mar 2023)
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation
- Selina Bopp,
- Charisse Flerida A. Pasaje,
- Robert L. Summers,
- Pamela Magistrado-Coxen,
- Kyra A. Schindler,
- Victoriano Corpas-Lopez,
- Tomas Yeo,
- Sachel Mok,
- Sumanta Dey,
- Sebastian Smick,
- Armiyaw S. Nasamu,
- Allison R. Demas,
- Rachel Milne,
- Natalie Wiedemar,
- Victoria Corey,
- Maria De Gracia Gomez-Lorenzo,
- Virginia Franco,
- Angela M. Early,
- Amanda K. Lukens,
- Danny Milner,
- Jeremy Furtado,
- Francisco-Javier Gamo,
- Elizabeth A. Winzeler,
- Sarah K. Volkman,
- Maëlle Duffey,
- Benoît Laleu,
- David A. Fidock,
- Susan Wyllie,
- Jacquin C. Niles,
- Dyann F. Wirth
Affiliations
- Selina Bopp
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Charisse Flerida A. Pasaje
- Department of Biological Engineering, Massachusetts Institute of Technology
- Robert L. Summers
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Pamela Magistrado-Coxen
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Kyra A. Schindler
- Department of Microbiology and Immunology, Columbia University Irving Medical Center
- Victoriano Corpas-Lopez
- Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee
- Tomas Yeo
- Department of Microbiology and Immunology, Columbia University Irving Medical Center
- Sachel Mok
- Department of Microbiology and Immunology, Columbia University Irving Medical Center
- Sumanta Dey
- Department of Biological Engineering, Massachusetts Institute of Technology
- Sebastian Smick
- Department of Biological Engineering, Massachusetts Institute of Technology
- Armiyaw S. Nasamu
- Department of Biological Engineering, Massachusetts Institute of Technology
- Allison R. Demas
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Rachel Milne
- Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee
- Natalie Wiedemar
- Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee
- Victoria Corey
- Department of Pediatrics, University of California, San Diego, School of Medicine
- Maria De Gracia Gomez-Lorenzo
- Tres Cantos Medicines Research and Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos
- Virginia Franco
- Tres Cantos Medicines Research and Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos
- Angela M. Early
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Amanda K. Lukens
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Danny Milner
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Jeremy Furtado
- Department of Nutrition, Harvard T.H. Chan School of Public Health
- Francisco-Javier Gamo
- Tres Cantos Medicines Research and Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos
- Elizabeth A. Winzeler
- Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center
- Sarah K. Volkman
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- Maëlle Duffey
- Medicines for Malaria Venture
- Benoît Laleu
- Medicines for Malaria Venture
- David A. Fidock
- Department of Microbiology and Immunology, Columbia University Irving Medical Center
- Susan Wyllie
- Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee
- Jacquin C. Niles
- Department of Biological Engineering, Massachusetts Institute of Technology
- Dyann F. Wirth
- Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health
- DOI
- https://doi.org/10.1038/s41467-023-36921-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
Drug resistance to current antimalarials is rising and new drugs and targets are urgently needed. Here the authors identify Plasmodium falciparum acyl-CoA synthetase 10 as a new target whose inhibition leads to a decrease in triacylglycerols.
