Asian Journal of Pharmaceutical Sciences (Nov 2017)

Enhanced dissolution of poorly soluble antiviral drugs from nanoparticles of cellulose acetate based solid dispersion matrices

  • Sonal Mazumder,
  • Ashish Kumar Dewangan,
  • Naresh Pavurala

DOI
https://doi.org/10.1016/j.ajps.2017.07.002
Journal volume & issue
Vol. 12, no. 6
pp. 532 – 541

Abstract

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Polysaccharide-based polymers were used to produce nanoparticles of poorly soluble antiviral drugs using a rapid precipitation process. The structure-property relationships of four novel cellulose acetate-based polymers were studied for their solubility enhancement of poorly soluble drugs. Particles were purified by dialysis, and dried powders were recovered after freeze-drying. The particle diameters were 150–200 nm. The target drug loading in the particles was 25 wt%, and the drug loading efficiencies were 80–96%. The effects of the formulation process and nanoparticle properties on drug solubility were investigated. All nanoparticles afforded increased solubility and faster release compared to pure drugs. Drug release was a function of the relative hydrophobicity (or solubility parameters) of the polymers.

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