Case Report: Recurrent Autoimmune Hypoglycemia Induced by Non-Hypoglycemic Medications

Qiuping Zhu; Qiuping Zhu; Hanxin Zhao; Wei Qiu; Fang Wu; Chungen Qian; Chungen Qian; Yonghong Yang; Ye Kang; Fenping Zheng; Jiaqiang Zhou

doi:10.3389/fimmu.2022.855350

Frontiers in Immunology (Jul 2022)

Case Report: Recurrent Autoimmune Hypoglycemia Induced by Non-Hypoglycemic Medications

Qiuping Zhu,
Qiuping Zhu,
Hanxin Zhao,
Wei Qiu,
Fang Wu,
Chungen Qian,
Chungen Qian,
Yonghong Yang,
Ye Kang,
Fenping Zheng,
Jiaqiang Zhou

Affiliations

Qiuping Zhu: Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Qiuping Zhu: Department of Endocrinology, Haining People’s Hospital, Haining, China
Hanxin Zhao: Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Wei Qiu: Department of Endocrinology, Huzhou Central Hospital, Huzhou, China
Fang Wu: Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Chungen Qian: College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China
Chungen Qian: Reagent R&D Center, Shenzhen YHLO Biotech Co., Ltd, Shenzhen, China
Yonghong Yang: Reagent R&D Center, Shenzhen YHLO Biotech Co., Ltd, Shenzhen, China
Ye Kang: Reagent R&D Center, Shenzhen YHLO Biotech Co., Ltd, Shenzhen, China
Fenping Zheng: Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Jiaqiang Zhou: Department of Endocrinology and Metabolism, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China

DOI: https://doi.org/10.3389/fimmu.2022.855350
Journal volume & issue: Vol. 13

Abstract

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We present a case of recurrent autoimmune hypoglycemia induced by non-hypoglycemic agents. We review reported cases of autoimmune hypoglycemia related to non-hypoglycemic agents, and discuss the effects of different detection methods for insulin autoantibodies on the results obtained. We aim to provide information for clinicians and a warning for medication usage. Considering the increasing number of clopidogrel-induced AIH cases and the hypoglycemia-induced increase in the risk of cardiovascular events, we recommend that cardiovascular disease patients being treated with clopidogrel be informed of this rare side effect and that clinicians be vigilant for the possibility of autoimmune hypoglycemia in this patient population.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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