Exosomal MIF Derived From Nasopharyngeal Carcinoma Promotes Metastasis by Repressing Ferroptosis of Macrophages

Wenhui Chen; Wenhui Chen; Fan Zuo; Kaiwen Zhang; Kaiwen Zhang; Tian Xia; Tian Xia; Wei Lei; Wei Lei; Zixiang Zhang; Zixiang Zhang; Lili Bao; Lili Bao; Yiwen You; Yiwen You

doi:10.3389/fcell.2021.791187

Frontiers in Cell and Developmental Biology (Dec 2021)

Exosomal MIF Derived From Nasopharyngeal Carcinoma Promotes Metastasis by Repressing Ferroptosis of Macrophages

Wenhui Chen,
Wenhui Chen,
Fan Zuo,
Kaiwen Zhang,
Kaiwen Zhang,
Tian Xia,
Tian Xia,
Wei Lei,
Wei Lei,
Zixiang Zhang,
Zixiang Zhang,
Lili Bao,
Lili Bao,
Yiwen You,
Yiwen You

Affiliations

Wenhui Chen: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Wenhui Chen: Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Fan Zuo: Department of Stomatology, Affiliated Hospital of Nantong University, Nantong, China
Kaiwen Zhang: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Kaiwen Zhang: Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Tian Xia: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Tian Xia: Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Wei Lei: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Wei Lei: Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Zixiang Zhang: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Zixiang Zhang: Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Lili Bao: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Lili Bao: Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Yiwen You: Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China
Yiwen You: Institute of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, China

DOI: https://doi.org/10.3389/fcell.2021.791187
Journal volume & issue: Vol. 9

Abstract

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Nasopharyngeal carcinoma (NPC) is the most common malignant tumor of the head and neck cancer (HNC). Metastasis is the main cause of treatment failure. However, the molecular mechanism for NPC metastasis is still unclear. As one of the most common host immune cells in the tumor microenvironment, macrophages have been proven to regulate metastasis. Besides, exosomes are the important bridge connecting various cells in TME. Currently, the role of NPC-exos on macrophages and their impact on metastasis remains to be unexplored. In this study, we found that MIF was highly expressed in NPC cells, and the exosomes secreted by NPC cells could be taken up by macrophages, thereby, inhibiting the ferroptosis of macrophages and then promoting the metastasis of NPC. Targeting MIF may be a potential treatment to reduce the rate of metastasis.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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