Prognostic Value of Blood Urea Nitrogen for Short-Term Mortality in Patients with Infective Endocarditis

Abstract

Abstract Introduction Blood urea nitrogen (BUN) is a metabolic product validated to be an independent risk factor in the prognosis of several diseases. However, the prognostic value of BUN in patients with infective endocarditis (IE) remains unevaluated. Methods A total of 1371 patients with a diagnosis of IE were included and divided into four groups according to BUN (mmol/L) at admission: 6.8 mmol/L had a higher 6-month mortality than other groups (log rank = 97.9, P 6.8 mmol/L was an independent predictor indicator for both in-hospital [adjusted odds ratio (aOR) = 2.365, 95% confidence interval (CI) 1.292–4.328, P = 0.005] and 6-month mortality [adjusted hazard ratio (aHR) = 2.171, 95% CI 1.355–3.479, P = 0.001]. Conclusions BUN is suitable for independently predicting short-term mortality in patients with IE.

Keywords

• Infective endocarditis
• Blood urea nitrogen
• Prognosis
• Hyperazotemia