Generation of a control iPS cell line (JUCGRMi006-A) with no abnormalities in Parkinson's disease-related genes

Kei-ichi Ishikawa; Takahiro Shiga; Manabu Funayama; Nobutaka Hattori; Wado Akamatsu

Stem Cell Research (Feb 2024)

Generation of a control iPS cell line (JUCGRMi006-A) with no abnormalities in Parkinson's disease-related genes

Kei-ichi Ishikawa,
Takahiro Shiga,
Manabu Funayama,
Nobutaka Hattori,
Wado Akamatsu

Affiliations

Kei-ichi Ishikawa: Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Department of Research and Development for Organoids, Juntendo University School of Medicine, Tokyo, Japan; Corresponding author.
Takahiro Shiga: Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
Manabu Funayama: Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan
Nobutaka Hattori: Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; Department of Research and Development for Organoids, Juntendo University School of Medicine, Tokyo, Japan; Neurodegenerative Disorders Collaborative Laboratory, RIKEN Center for Brain Science, Saitama, Japan
Wado Akamatsu: Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Journal volume & issue: Vol. 74
p. 103270

Abstract

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The appropriate control of induced pluripotent stem cells (iPSCs) is essential for studying iPSCs derived from patients with Parkinson’s disease (PD). Here, we established an iPSC line from a healthy female donor. The iPSCs were pluripotent, could differentiate into three germ layers, and had normal karyotypes. We also confirmed that the iPSC line exhibited no PD-related gene abnormalities. This iPSC line will be useful for PD research.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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