Pharmaceutics (May 2023)

Fe-Based Metal Organic Frameworks (Fe-MOFs) for Bio-Related Applications

  • Rongyue Zhu,
  • Mengru Cai,
  • Tingting Fu,
  • Dongge Yin,
  • Hulinyue Peng,
  • Shilang Liao,
  • Yuji Du,
  • Jiahui Kong,
  • Jian Ni,
  • Xingbin Yin

DOI
https://doi.org/10.3390/pharmaceutics15061599
Journal volume & issue
Vol. 15, no. 6
p. 1599

Abstract

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Metal–organic frameworks (MOFs) are porous materials composed of metal ions and organic ligands. Due to their large surface area, easy modification, and good biocompatibility, MOFs are often used in bio-related fields. Fe-based metal–organic frameworks (Fe-MOFs), as important types of MOF, are favored by biomedical researchers for their advantages, such as low toxicity, good stability, high drug-loading capacity, and flexible structure. Fe-MOFs are diverse and widely used. Many new Fe-MOFs have appeared in recent years, with new modification methods and innovative design ideas, leading to the transformation of Fe-MOFs from single-mode therapy to multi-mode therapy. In this paper, the therapeutic principles, classification, characteristics, preparation methods, surface modification, and applications of Fe-MOFs in recent years are reviewed to understand the development trends and existing problems in Fe-MOFs, with the view to provide new ideas and directions for future research.

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