An update on adverse health effects from exposure to PM2.5

Sarawut Sangkham; Worradorn Phairuang; Samendra P. Sherchan; Nattapon Pansakun; Narongsuk Munkong; Kritsada Sarndhong; Md. Aminul Islam; Pornpun Sakunkoo

Environmental Advances (Dec 2024)

An update on adverse health effects from exposure to PM2.5

Sarawut Sangkham,
Worradorn Phairuang,
Samendra P. Sherchan,
Nattapon Pansakun,
Narongsuk Munkong,
Kritsada Sarndhong,
Md. Aminul Islam,
Pornpun Sakunkoo

Affiliations

Sarawut Sangkham: Department of Environmental Health, School of Public Health, University of Phayao, Muang District, Phayao 56000, Thailand; Corresponding authors.
Worradorn Phairuang: Faculty of Geosciences and Civil Engineering, Institute of Science and Engineering, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan; Department of Geography, Faculty of Social Sciences, Chiang Mai University, Muang, Chiang Mai 50200, Thailand
Samendra P. Sherchan: Department of Environmental Health Sciences, Tulane University, 1440 Canal Street, Suite 2100, New Orleans, LA 70112, USA; Center of Research Excellence in Wastewater based Epidemiology, Morgan State University, Baltimore, MD, USA
Nattapon Pansakun: Department of Health Promotion, School of Public Health, University of Phayao, Muang District, Phayao 56000, Thailand
Narongsuk Munkong: Department of Pathology, School of Medicine, University of Phayao, Muang District, Phayao 56000, Thailand
Kritsada Sarndhong: Department of Community Health, School of Public Health, University of Phayao, Phayao 56000, Thailand
Md. Aminul Islam: COVID-19 Diagnostic Lab, Department of Microbiology, Noakhali Science and Technology University, Noakhali 3814, Bangladesh; Advanced Molecular Lab, Department of Microbiology, President Abdul Hamid Medical College, Karimganj, Kishoreganj, Bangladesh
Pornpun Sakunkoo: Department of Environmental Health Occupational Health and Safety, Faculty of Public Health, Khon Kaen University, Muang District, Khon Kaen 40002, Thailand; Corresponding authors.

Journal volume & issue: Vol. 18
p. 100603

Abstract

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The impact of fine particulate matter (PM2.5) on public health has become a global concern due to the mortality and morbidity it entails. Pathophysiological and epidemiological studies have demonstrated an association between PM2.5 and respiratory diseases, cardiovascular diseases, and neurological disorders. The underlying mechanisms through which PM2.5 adversely affects human health include the induction of oxidative stress, cytokine release, deoxyribonucleic acid (DNA) damage, altered gene expression, immune toxicity, inflammatory responses, and apoptosis. These outcomes drive the initiation and progression of various diseases. Notably, exposure to PM2.5 containing chemical compounds may translocate and induce unbalanced intracellular functions at the genetic and epigenetic levels, leading to mutations, carcinogenesis, and multiple diseases. This review aims to summarise and discuss recent updates on the mechanisms linking PM2.5 exposure to adverse health, highlighting the critical connection between PM2.5 and health outcomes, with the hope of raising awareness and promoting measures to reduce PM2.5 levels worldwide.

Published in Environmental Advances

ISSN: 2666-7657 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/environmental-advances

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