Nature Communications (Jan 2021)

Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells

  • Lara Ribeiro-Parenti,
  • Anne-Charlotte Jarry,
  • Jean-Baptiste Cavin,
  • Alexandra Willemetz,
  • Johanne Le Beyec,
  • Aurélie Sannier,
  • Samira Benadda,
  • Anne-Laure Pelletier,
  • Muriel Hourseau,
  • Thibaut Léger,
  • Bastien Morlet,
  • Anne Couvelard,
  • Younes Anini,
  • Simon Msika,
  • Jean-Pierre Marmuse,
  • Sévérine Ledoux,
  • Maude Le Gall,
  • André Bado

DOI
https://doi.org/10.1038/s41467-020-20301-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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GLP-1 is a gastrointestinal peptide that regulates gastric acid secretion and emptying, and due to the rapid degradation of intestinally secreted GLP-1 local gastric production has been suggested. Here the authors report the presence of GLP-1 expressing cells in the rat and human stomach, which contribute to the circulating GLP-1 levels and are affected by weight loss surgeries.