Viruses (Nov 2021)
Epidemiological and Immunological Features of Obesity and SARS-CoV-2
- Eric J. Nilles,
- Sameed M. Siddiqui,
- Stephanie Fischinger,
- Yannic C. Bartsch,
- Michael de St. Aubin,
- Guohai Zhou,
- Matthew J. Gluck,
- Samuel Berger,
- Justin Rhee,
- Eric Petersen,
- Benjamin Mormann,
- Michael Loesche,
- Yiyuan Hu,
- Zhilin Chen,
- Jingyou Yu,
- Makda Gebre,
- Caroline Atyeo,
- Matthew J. Gorman,
- Alex Lee Zhu,
- John Burke,
- Matthew Slein,
- Mohammad A. Hasdianda,
- Guruprasad Jambaulikar,
- Edward W. Boyer,
- Pardis C. Sabeti,
- Dan H. Barouch,
- Boris Julg,
- Adam J. Kucharski,
- Elon R. Musk,
- Douglas A. Lauffenburger,
- Galit Alter,
- Anil S. Menon
Affiliations
- Eric J. Nilles
- Brigham and Women’s Hospital, Boston, MA 02115, USA
- Sameed M. Siddiqui
- Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
- Stephanie Fischinger
- Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
- Yannic C. Bartsch
- Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
- Michael de St. Aubin
- Harvard Humanitarian Initiative, Boston, MA 02114, USA
- Guohai Zhou
- Brigham and Women’s Hospital, Boston, MA 02115, USA
- Matthew J. Gluck
- Space Exploration Technologies Corp., Hawthorne, CA 90250, USA
- Samuel Berger
- Space Exploration Technologies Corp., Hawthorne, CA 90250, USA
- Justin Rhee
- Space Exploration Technologies Corp., Hawthorne, CA 90250, USA
- Eric Petersen
- Space Exploration Technologies Corp., Hawthorne, CA 90250, USA
- Benjamin Mormann
- Brigham and Women’s Hospital, Boston, MA 02115, USA
- Michael Loesche
- Brigham and Women’s Hospital, Boston, MA 02115, USA
- Yiyuan Hu
- Space Exploration Technologies Corp., Hawthorne, CA 90250, USA
- Zhilin Chen
- Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
- Jingyou Yu
- Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
- Makda Gebre
- Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
- Caroline Atyeo
- Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
- Matthew J. Gorman
- Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
- Alex Lee Zhu
- Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
- John Burke
- Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
- Matthew Slein
- Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA
- Mohammad A. Hasdianda
- Brigham and Women’s Hospital, Boston, MA 02115, USA
- Guruprasad Jambaulikar
- Brigham and Women’s Hospital, Boston, MA 02115, USA
- Edward W. Boyer
- Brigham and Women’s Hospital, Boston, MA 02115, USA
- Pardis C. Sabeti
- Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA
- Dan H. Barouch
- Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Boris Julg
- Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
- Adam J. Kucharski
- London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
- Elon R. Musk
- Space Exploration Technologies Corp., Hawthorne, CA 90250, USA
- Douglas A. Lauffenburger
- Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
- Galit Alter
- Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA
- Anil S. Menon
- Space Exploration Technologies Corp., Hawthorne, CA 90250, USA
- DOI
- https://doi.org/10.3390/v13112235
- Journal volume & issue
-
Vol. 13,
no. 11
p. 2235
Abstract
Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and remarkably homogenous immune activity across BMI categories suggests immune protection across these groups may be similar.
Keywords
