Frontiers in Immunology (Apr 2023)
Effects of obesity with reduced 25(OH)D levels on bone health in elderly Chinese people: a nationwide cross-sectional study
- Chunchun Yuan,
- Chunchun Yuan,
- Chunchun Yuan,
- Jing Wang,
- Jing Wang,
- Jing Wang,
- Weiqiang Zhang,
- Weiqiang Zhang,
- Honggang Yi,
- Bing Shu,
- Bing Shu,
- Bing Shu,
- Bing Shu,
- Chenguang Li,
- Chenguang Li,
- Chenguang Li,
- Chenguang Li,
- Qianqian Liang,
- Qianqian Liang,
- Qianqian Liang,
- Qianqian Liang,
- De Liang,
- Bolai Chen,
- Bolai Chen,
- Xingwen Xie,
- Xingwen Xie,
- Xinchao Lin,
- Xu Wei,
- Hui Wang,
- Peizhan Chen,
- Chen Huang,
- Chen Huang,
- Chen Huang,
- Hao Xu,
- Hao Xu,
- Hao Xu,
- Yueli Sun,
- Yueli Sun,
- Yueli Sun,
- Yongjian Zhao,
- Yongjian Zhao,
- Yongjian Zhao,
- Qi Shi,
- Qi Shi,
- Qi Shi,
- Qi Shi,
- Dezhi Tang,
- Dezhi Tang,
- Dezhi Tang,
- Dezhi Tang,
- Yongjun Wang,
- Yongjun Wang,
- Yongjun Wang,
- Yongjun Wang
Affiliations
- Chunchun Yuan
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Chunchun Yuan
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Chunchun Yuan
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Jing Wang
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Jing Wang
- Shanghai Geriatric Institute of Chinese Medicine, Shanghai, China
- Jing Wang
- Academic Research Center of Shixiaoshan’ Traumatology, Shanghai, China
- Weiqiang Zhang
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Weiqiang Zhang
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China
- Honggang Yi
- Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China
- Bing Shu
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Bing Shu
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Bing Shu
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Bing Shu
- Academic Research Center of Shixiaoshan’ Traumatology, Shanghai, China
- Chenguang Li
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Chenguang Li
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Chenguang Li
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Chenguang Li
- Academic Research Center of Shixiaoshan’ Traumatology, Shanghai, China
- Qianqian Liang
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qianqian Liang
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qianqian Liang
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Qianqian Liang
- Academic Research Center of Shixiaoshan’ Traumatology, Shanghai, China
- De Liang
- The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Bolai Chen
- Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
- Bolai Chen
- 0The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Xingwen Xie
- 1The Second People’s Hospital of Gansu Province, Gansu, Lanzhou, China
- Xingwen Xie
- 2Affiliated Hospital of Northwest University for Nationalities, Gansu, Lanzhou, China
- Xinchao Lin
- 3Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
- Xu Wei
- 4Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
- Hui Wang
- 5State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Peizhan Chen
- 6Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Chen Huang
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Chen Huang
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Chen Huang
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Hao Xu
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Hao Xu
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Hao Xu
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Yueli Sun
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Yueli Sun
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Yueli Sun
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Yongjian Zhao
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Yongjian Zhao
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Yongjian Zhao
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Qi Shi
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qi Shi
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Qi Shi
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Qi Shi
- Academic Research Center of Shixiaoshan’ Traumatology, Shanghai, China
- Dezhi Tang
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Dezhi Tang
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Dezhi Tang
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Dezhi Tang
- Academic Research Center of Shixiaoshan’ Traumatology, Shanghai, China
- Yongjun Wang
- Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Yongjun Wang
- Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Yongjun Wang
- Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education (Shanghai University of Traditional Chinese Medicine), Shanghai, China
- Yongjun Wang
- Academic Research Center of Shixiaoshan’ Traumatology, Shanghai, China
- DOI
- https://doi.org/10.3389/fimmu.2023.1162175
- Journal volume & issue
-
Vol. 14
Abstract
BackgroundObesity is often accompanied by lower 25(OH)D levels, whereas these two parameters exhibit opposite effects on bone health. It is uncertain what are the effects of lower 25(OH)D levels in obesity on bone health in elderly Chinese people.MethodsA nationally representative cross-sectional analysis of China Community-based Cohort of Osteoporosis (CCCO) was performed from 2016 to 2021, which consisted of 22,081 participants. Demographic data, disease history, Body mass index (BMI), bone mineral density (BMD), the levels of the biomarkers of vitamin D status and those of bone metabolism markers were measured for all participants (N = 22,081). The genes (rs12785878, rs10741657, rs4588, rs7041, rs2282679 and rs6013897) related to 25(OH)D transportation and metabolism were performed in a selected subgroup (N = 6008).ResultsObese subjects exhibited lower 25(OH)D levels (p < 0.05) and higher BMD (p < 0.001) compared with those of normal subjects following adjustment. The genotypes and allele frequency of rs12785878, rs10741657, rs6013897, rs2282679, rs4588 and rs7041 indicated no significant differences among three BMI groups following correction by the Bonferroni’s method (p > 0.05). The levels of total 25(OH)D (ToVD) were significantly different among the GC1F, GC1S and GC2 haplotype groups (p < 0.05). Correlation analysis indicated that ToVD levels were significantly correlated with parathyroid hormone levels, BMD, risk of osteoporosis (OP) and the concentration levels of other bone metabolism markers (p < 0.05). Generalized varying coefficient models demonstrated that the increasing BMI, ToVD levels and their interactions were positively associated with BMD outcomes (p < 0.001), whereas the reduced levels of ToVD and BMI increased the risk of OP, which was noted notably for the subjects with reduced ToVD levels (less than 20.69 ng/ml) combined with decreased BMI (less than 24.05 kg/m2).ConclusionThere was a non-linear interaction of BMI and 25(OH)D. And higher BMI accompanied by decreased 25(OH)D levels is associated with increased BMD and decreased incidence of OP, optimal ranges exist for BMI and 25(OH)D levels. The cutoff value of BMI at approximately 24.05 kg/m2 combined with an approximate value of 25(OH)D at 20.69 ng/ml are beneficial for Chinese elderly subjects.
Keywords
