Severe acidosis due to 5-oxoprolinase inhibition by flucloxacillin in a patient with shoulder prosthesis joint infection

J. E. Lenz; V. Alt; T. Dienemann

doi:10.5194/jbji-7-71-2022

Journal of Bone and Joint Infection (Apr 2022)

Severe acidosis due to 5-oxoprolinase inhibition by flucloxacillin in a patient with shoulder prosthesis joint infection

J. E. Lenz,
V. Alt,
T. Dienemann

Affiliations

J. E. Lenz: Department of Trauma Surgery, University Medical Center Regensburg, Regensburg, Germany
V. Alt: Department of Trauma Surgery, University Medical Center Regensburg, Regensburg, Germany
T. Dienemann: Department of Surgery, Surgical Intensive Care Unit, University Medical Center Regensburg, Regensburg, Germany

DOI: https://doi.org/10.5194/jbji-7-71-2022
Journal volume & issue: Vol. 7
pp. 71 – 74

Abstract

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We report a case of a 64-year-old female patient with severe metabolic acidosis. Inhibition of 5-oxoprolinase by flucloxacillin was found to be the cause of the metabolic derailment.

Published in Journal of Bone and Joint Infection

ISSN: 2206-3552 (Online)
Publisher: Copernicus Publications
Country of publisher: Germany
LCC subjects: Medicine: Surgery: Orthopedic surgery
Website: https://www.journal-of-bone-and-joint-infection.net/

About the journal