Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins

Abstract

Ciliary extracellular vesicles (ciEVs), released from primary cilia, contain functional proteins that play an important role in cilia structure and functions. We have recently shown that ciEVs and cytosolic extracellular vesicles (cyEVs) have unique and distinct biomarkers. While ciEV biomarkers have shown some interactions with known ciliary proteins, little is known about the interaction of ciEV proteins with proteins involved in ciliopathy and neurodegenerative disorders. Here, we reveal for the first time the protein-protein interaction (PPI) between the top five ciEVs biomarkers with ciliopathy and Alzheimer disease (AD) proteins. These results support the growing evidence of the critical physiological roles of cilia in neurodegenerative disorders.

Keywords

• ciliary extracellular vesicles
• cytosolic extracellular vesicles
• exosome
• ectosome
• primary cilia
• ciliopathy disorders
• alzheimer disease
• neurodegenerative disorders
• bioinformatic
• proteomics
• biomarkers