Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases

• Caroline Chandra Tjin,
• Kate D. Otley,
• Tyler D. Baguley,
• Pradeep Kurup,
• Jian Xu,
• Angus C. Nairn,
• Paul J. Lombroso,
• Jonathan A. Ellman

Affiliations

Caroline Chandra Tjin

Department of Chemistry, Yale University, New Haven, Connecticut, United States

Kate D. Otley

Department of Chemistry, Yale University, New Haven, Connecticut, United States

Tyler D. Baguley

Department of Chemistry, Yale University, New Haven, Connecticut, United States

Pradeep Kurup

The Child Study Center, Yale University School of Medicine, New Haven, Connecticut, United States

Jian Xu

The Child Study Center, Yale University School of Medicine, New Haven, Connecticut, United States

Angus C. Nairn

Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States

Paul J. Lombroso

The Child Study Center, Yale University School of Medicine, New Haven, Connecticut, United States

Jonathan A. Ellman

Department of Chemistry, Yale University, New Haven, Connecticut, United States