Our Celiac Disease Experience: Demographic Characteristics, Laboratory Findings and Concomitant Diseases of 94 Patients

Abstract

Aim: Celiac Disease (CD) which is an autoimmune disease affecting 1% of the population is associated with other autoimmune diseases and has extraintestinal manifestations. In the present study, we investigated the demographic and laboratory data of 94 patients and diseases related to anemia, osteoporosis and other autoimmune diseases. Material and Method: This study was conducted retrospectively by examining the records of 94 patients who were followed up with the diagnosis of CD between January 2014 and December 2019. Results: Of the patients, 74 were female (79%), 20 were male (21%). The mean age of the patients was 35 (18-73). The average disease duration was 6.6 years (0-29). Anti-endomysium Ig A positivity in 81 patients (86%), tissue transglutaminase Ig A positivity in 87 patients (93%), and tissue transglutaminase IgG positivity in 45 patients (48%) were detected. 14 patients had hypothyroidism (15%) and 8 patients had diabetes mellitus (9%). Osteoporosis or osteopenia was detected in 61 patients as the result of bone mineral densitometry (65%). According to the ferritin results, half of the patients and according to the transferrin saturation result, 47% had iron deficiency. 13 patients had B12 deficiency (14%) and 24 patients had folic acid deficiency (26%). Vitamin D deficiency was found in 74% of the patients. TSH value was found over 4.5 mIU/L in 10 patients. Conclusion: CD is associated with iron, folate, vitamin B12, and vitamin D deficiency and is associated with anemia and osteoporosis, and the disease is often accompanied by autoimmune thyroid diseases and diabetes.

Keywords

• çölyak hastalığı
• hipotiroidi
• osteoporoz
• anemi
• celiac disease
• hypothyroidism
• osteoporosis
• anemia