YAP determines the cell fate of injured mouse hepatocytes in vivo

Norio Miyamura; Shoji Hata; Tohru Itoh; Minoru Tanaka; Miki Nishio; Michiko Itoh; Yoshihiro Ogawa; Shuji Terai; Isao Sakaida; Akira Suzuki; Atsushi Miyajima; Hiroshi Nishina

doi:10.1038/ncomms16017

Nature Communications (Jul 2017)

YAP determines the cell fate of injured mouse hepatocytes in vivo

Norio Miyamura,
Shoji Hata,
Tohru Itoh,
Minoru Tanaka,
Miki Nishio,
Michiko Itoh,
Yoshihiro Ogawa,
Shuji Terai,
Isao Sakaida,
Akira Suzuki,
Atsushi Miyajima,
Hiroshi Nishina

Affiliations

Norio Miyamura: Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU)
Shoji Hata: Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU)
Tohru Itoh: Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo
Minoru Tanaka: Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine
Miki Nishio: Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine
Michiko Itoh: Department of Organ Network and Metabolism, Graduate School of Medical and Dental Sciences
Yoshihiro Ogawa: Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, TMDU, AMED-CREST
Shuji Terai: Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University
Isao Sakaida: Department of Gastroenterology and Hepatology, Graduate School of Medicine, Yamaguchi University
Akira Suzuki: Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine
Atsushi Miyajima: Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo
Hiroshi Nishina: Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University (TMDU)

DOI: https://doi.org/10.1038/ncomms16017
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Senescent and injured cells affect tissue functions and can drive tumorigenesis. Thus, efficient elimination of these cells is pivotal for tissue integrity. Here Miyamuraet al. show that YAP acts as a cellular stress sensor and promotes the elimination of damaged cells to maintain tissue homeostasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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