Effects of Ginger Extract on Hyperlipidemic Diet Induced Non Acholic Fatty Liver Disease

Abstract

Objective: To determine the effects of ginger extract on the histomorphological changes of fatty liver of hyperlipidemic diet induced NAFLD. Study Design: It was randomized control trial. Place and Duration of Study: The study was carried out from October 2012 to March 2013, in the department of Anatomy,Islamic International Medical College, Rawalpindi, in collaboration with National Institute of Health (NIH),Islamabad. Materials and Methods: A total of 35 male albino mice were used and divided into 3 groups. The control group (C) was fed on normal laboratory diet, while the remaining two groups, fatty group (FG), ginger group (GN), were fed on hyperlipidemic diet for twelve weeks to induce hyperlipidemia/nonalcoholic fatty liver. Then GN group with induced hyperlipidemia/ fatty liver was administered normal laboratory diet with ginger extract as a drink in replacement of water for another twelve weeks. Results: Total body weight was reduced as compared to their initial body weights. The histological examinations of this study revealed reverse fatty (steatotic) changes and showed marked reduction in number of fat globules, ballooning degeneration, glycogenated nuclei. Conclusion: This research shows that ginger extract has marked antihepatotoxic effects. Ginger extract ameliorates high fat induced fatty liver disease.

Keywords

• nonalcoholic fatty liver disease, hyperlipidemia, steatotic, glycogenated nucleiand ginger.