EFFECTS OF DRY ENZYMATIC LYSATE DEL-IMMUNE V® ON CYTOKINE PRODUCTION IN THE EXPERIMENTAL MODELS

Abstract

Prior testing of Del-Immune V® has indicated effectiveness for immune system support; however, mechanisms of action and optimal doses have not been researched yet. It is shown that the drug Del-Immune V®, a dry enzyme lysate of the strain Lactobacillus rhamnosus V, containing muramyl peptides and DNA fragments in the range of doses of 5–500 mg/mouse (optimum 50 mg/mouse) is an active inducer of IFN, it affects the production factor of tumor necrosis (TNF) in systems in vivo and in vitro. Its inducing activity is comparable with the data obtained while using complex probiotic Bifidim, but the live cells of bifidobacteria, being a part of the drug more efficiently stimulated production of TNF in vitro in comparison with Del-ImmuneV®. The levels of cytokine production under the influence of drugs in the in vivo correlated with the production of cytokines in the system in vitro. The highest serum IFN level was reported 24 hours after the drugs administration. The control group remained unchanged. Maintenance of elevated circulating IFN was possible only through repeated administration.

Keywords

• del-immune v®
• lactobacillus rhamnosus v
• пробіотик біфідим
• інтерферон
• фактор некрозу пухлини
• імунна система