Allosteric Activation of SARS-CoV-2 RNA-Dependent RNA Polymerase by Remdesivir Triphosphate and Other Phosphorylated Nucleotides

mBio (Jun 2021)

Affiliations

Bing Wang: ORCiD; Department of Microbiology, The Ohio State University, Columbus, Ohio, USA
Vladimir Svetlov: ORCiD; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA
Yuri I. Wolf: ORCiD; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
Eugene V. Koonin: ORCiD; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA
Evgeny Nudler: Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA
Irina Artsimovitch: ORCiD; Department of Microbiology, The Ohio State University, Columbus, Ohio, USA

Abstract

In vitro