Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages

Abstract

Microglia and peripheral myeloid cells are critically involved in the immunopathology of glioblastoma. Here the authors present single-cell sequencing data that assesses the phenotypic composition of CD11b + myeloid cells from a murine model of glioblastoma and suggest enhanced MHCII transcription which they additionally report from human cases of glioblastoma.