Tumor-infiltrating mast cells confer resistance to immunotherapy in pancreatic cancer

Ying Ma; Xiangqin Zhao; Jingyan Feng; Suimin Qiu; Baoan Ji; Lu Huang; Patrick Hwu; Craig D. Logsdon; Huamin Wang

iScience (Nov 2024)

Tumor-infiltrating mast cells confer resistance to immunotherapy in pancreatic cancer

Ying Ma,
Xiangqin Zhao,
Jingyan Feng,
Suimin Qiu,
Baoan Ji,
Lu Huang,
Patrick Hwu,
Craig D. Logsdon,
Huamin Wang

Affiliations

Ying Ma: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China; Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Department of Immunology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Corresponding author
Xiangqin Zhao: Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
Jingyan Feng: Seekgene Biotechnology Co, Ltd, Beijing 102200, China
Suimin Qiu: Department of Surgical Pathology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
Baoan Ji: Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA
Lu Huang: Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Patrick Hwu: Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Moffitt Cancer Center, Tampa, FL 33612, USA
Craig D. Logsdon: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Huamin Wang: Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA

Journal volume & issue: Vol. 27, no. 11
p. 111085

Abstract

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Summary: Pancreatic ductal adenocarcinoma (PDAC) exhibits an immunosuppressive tumor microenvironment (TME) contributing to its therapeutic resistance. Following our previous studies, we report that mast cells infiltrating the PDAC TME foster this immunosuppression and desmoplasia. Mast cell infiltration correlated with human PDAC progression, and genetic or pharmacological mast cell depletion reduced tumor growth and desmoplasia while enhancing survival in mouse PDAC models. Mechanistically, mast cell-derived IL-10 promoted PDAC progression. Strikingly, combining an agonistic anti-OX40 immunotherapy with mast cell blockade synergistically elicited durable anti-tumor immunity, marked by increased infiltration of CD8+ T effector cells expressing granzyme B and dramatic survival benefit unachievable with either approach alone. An OX40-associated gene signature correlated with improved survival in human PDAC, supporting therapeutic translation. Our findings establish mast cells as promoters of the suppressive PDAC TME and rational targets for combination immunotherapy. Targeting this mast cell-mediated resistance mechanism could overcome immunotherapy failure in PDAC.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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