Nature Communications (Feb 2019)
CIC protein instability contributes to tumorigenesis in glioblastoma
- Severa Bunda,
- Pardeep Heir,
- Julie Metcalf,
- Annie Si Cong Li,
- Sameer Agnihotri,
- Stefan Pusch,
- Mamatjan Yasin,
- Mira Li,
- Kelly Burrell,
- Sheila Mansouri,
- Olivia Singh,
- Mark Wilson,
- Amir Alamsahebpour,
- Romina Nejad,
- Bethany Choi,
- David Kim,
- Andreas von Deimling,
- Gelareh Zadeh,
- Kenneth Aldape
Affiliations
- Severa Bunda
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Pardeep Heir
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Julie Metcalf
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Annie Si Cong Li
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Sameer Agnihotri
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Stefan Pusch
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Mamatjan Yasin
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Mira Li
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Kelly Burrell
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Sheila Mansouri
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Olivia Singh
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Mark Wilson
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Amir Alamsahebpour
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Romina Nejad
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Bethany Choi
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- David Kim
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Andreas von Deimling
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Gelareh Zadeh
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- Kenneth Aldape
- MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre
- DOI
- https://doi.org/10.1038/s41467-018-08087-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Capicua (CIC) is a tumour suppressor in oligodendroglioma. Here, the authors show that ERK activation mediates CIC regulation via ubiquitination and degradation by PJA1 and a degradation resistant form of CIC enhances efficacy of ERK inhibition in glioblastoma.
