Nature Communications (Dec 2017)
Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex
- So Yeon Kim,
- Jong-Min Jeong,
- Soo Jin Kim,
- Wonhyo Seo,
- Myung-Ho Kim,
- Won-Mook Choi,
- Wonbeak Yoo,
- Jun-Hee Lee,
- Young-Ri Shim,
- Hyon-Seung Yi,
- Young-Sun Lee,
- Hyuk Soo Eun,
- Byung Seok Lee,
- Kwangsik Chun,
- Suk-Jo Kang,
- Sun Chang Kim,
- Bin Gao,
- George Kunos,
- Ho Min Kim,
- Won-Il Jeong
Affiliations
- So Yeon Kim
- Laboratory of Liver Research, Biomedical Science and Engineering Interdisciplinary Program, KAIST
- Jong-Min Jeong
- Laboratory of Liver Research, Biomedical Science and Engineering Interdisciplinary Program, KAIST
- Soo Jin Kim
- Graduate School of Medical Science and Engineering, KAIST
- Wonhyo Seo
- Laboratory of Liver Research, Biomedical Science and Engineering Interdisciplinary Program, KAIST
- Myung-Ho Kim
- Graduate School of Medical Science and Engineering, KAIST
- Won-Mook Choi
- Graduate School of Medical Science and Engineering, KAIST
- Wonbeak Yoo
- Graduate School of Medical Science and Engineering, KAIST
- Jun-Hee Lee
- Graduate School of Medical Science and Engineering, KAIST
- Young-Ri Shim
- Laboratory of Liver Research, Biomedical Science and Engineering Interdisciplinary Program, KAIST
- Hyon-Seung Yi
- Department of Internal Medicine, Chungnam National University School of Medicine
- Young-Sun Lee
- Department of Internal Medicine, Korea University College of Medicine
- Hyuk Soo Eun
- Department of Internal Medicine, Chungnam National University School of Medicine
- Byung Seok Lee
- Department of Internal Medicine, Chungnam National University School of Medicine
- Kwangsik Chun
- Department of Surgery, Chungnam National University School of Medicine
- Suk-Jo Kang
- Department of Biological Sciences, Korea Advanced Institute of Science and Technology
- Sun Chang Kim
- Department of Biological Sciences, Korea Advanced Institute of Science and Technology
- Bin Gao
- National Institutes of Health (NIH), National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- George Kunos
- National Institutes of Health (NIH), National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Ho Min Kim
- Graduate School of Medical Science and Engineering, KAIST
- Won-Il Jeong
- Laboratory of Liver Research, Biomedical Science and Engineering Interdisciplinary Program, KAIST
- DOI
- https://doi.org/10.1038/s41467-017-02325-2
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Reactive species of oxygen promote the development of hepatic steatosis. Here, Kim et al. demonstrate that palmitate stimulates macrophage infiltration and increases oxidative stress during steatosis by binding to the TLR4–MD2 complex, which results in the activation of NOX2.
