Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

Charles D. Cox; Chilman Bae; Lynn Ziegler; Silas Hartley; Vesna Nikolova-Krstevski; Paul R. Rohde; Chai-Ann Ng; Frederick Sachs; Philip A. Gottlieb; Boris Martinac

doi:10.1038/ncomms10366

Nature Communications (Jan 2016)

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

Charles D. Cox,
Chilman Bae,
Lynn Ziegler,
Silas Hartley,
Vesna Nikolova-Krstevski,
Paul R. Rohde,
Chai-Ann Ng,
Frederick Sachs,
Philip A. Gottlieb,
Boris Martinac

Affiliations

Charles D. Cox: Victor Chang Cardiac Research Institute
Chilman Bae: Department of Physiology and Biophysics, State University of New York at Buffalo
Lynn Ziegler: Department of Physiology and Biophysics, State University of New York at Buffalo
Silas Hartley: Department of Physiology and Biophysics, State University of New York at Buffalo
Vesna Nikolova-Krstevski: Victor Chang Cardiac Research Institute
Paul R. Rohde: Victor Chang Cardiac Research Institute
Chai-Ann Ng: Victor Chang Cardiac Research Institute
Frederick Sachs: Department of Physiology and Biophysics, State University of New York at Buffalo
Philip A. Gottlieb: Department of Physiology and Biophysics, State University of New York at Buffalo
Boris Martinac: Victor Chang Cardiac Research Institute

DOI: https://doi.org/10.1038/ncomms10366
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

PIEZO1 is a mechanosensitive ion channel, but the mechanism of force transduction is unknown. Here Cox and Bae et al.disrupt the cortical cytoskeleton in HEK293 cells to show that PIEZO1 is gated directly by membrane tension.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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