MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy

Abstract

Fukuoka et al. investigate the possible role of miR-199-3p during aging, which significantly decreases in the blood of aged mice compared to young mice. They also show that miR-199-3p enhance muscle regeneration, and administering miR-199 mimics to mdx mice, a dystrophy animal model, markedly improves muscle strength of the mice, highlighting its therapeutic potential.