Clinical characteristics and prognostic characterization of endometrial carcinoma: a comparative analysis of molecular typing protocols

Abstract

Highlights TCGA molecular classification has advantages over ProMisE classification for accurate diagnosis of endometrial carcinoma. Comparison among the four TCGA types (POLE, Low-CN, High-CN, and MSI-H) and age was statistically significant. Patients with POLE mutations and low-CN had higher PFS and overall survival, whereas those with high-CN had the lowest overall survival periods.

Keywords

• TCGA typing
• Endometrial carcinoma
• Prognosis analysis
• ProMisE typing
• Application value