Nature Communications (Feb 2021)
Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence
- Lingyan Jiang,
- Peisheng Wang,
- Xiaorui Song,
- Huan Zhang,
- Shuangshuang Ma,
- Jingting Wang,
- Wanwu Li,
- Runxia Lv,
- Xiaoqian Liu,
- Shuai Ma,
- Jiaqi Yan,
- Haiyan Zhou,
- Di Huang,
- Zhihui Cheng,
- Chen Yang,
- Lu Feng,
- Lei Wang
Affiliations
- Lingyan Jiang
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Peisheng Wang
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Xiaorui Song
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Huan Zhang
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Shuangshuang Ma
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Jingting Wang
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Wanwu Li
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Runxia Lv
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Xiaoqian Liu
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Shuai Ma
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Jiaqi Yan
- College of Life Sciences, Nankai University
- Haiyan Zhou
- CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences
- Di Huang
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Zhihui Cheng
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Chen Yang
- CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences
- Lu Feng
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- Lei Wang
- The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University
- DOI
- https://doi.org/10.1038/s41467-021-21186-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here, Jiang et al. show that infected macrophages exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates that promote intracellular replication and virulence of S. Typhimurium.
