Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer

Qin Dang; Qin Dang; Zaoqu Liu; Zaoqu Liu; Shengyun Hu; Zhuang Chen; Lingfang Meng; Junhong Hu; Guixian Wang; Weitang Yuan; Xinwei Han; Xinwei Han; Lifeng Li; Zhenqiang Sun; Zhenqiang Sun

doi:10.3389/fonc.2021.743703

Frontiers in Oncology (Oct 2021)

Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer

Qin Dang,
Qin Dang,
Zaoqu Liu,
Zaoqu Liu,
Shengyun Hu,
Zhuang Chen,
Lingfang Meng,
Junhong Hu,
Guixian Wang,
Weitang Yuan,
Xinwei Han,
Xinwei Han,
Lifeng Li,
Zhenqiang Sun,
Zhenqiang Sun

Affiliations

Qin Dang: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Qin Dang: Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
Zaoqu Liu: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Zaoqu Liu: Interventional Institute of Zhengzhou University, Zhengzhou, China
Shengyun Hu: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Zhuang Chen: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Lingfang Meng: Department of Ultrasound, Zhengzhou Sixth People’s Hospital, Henan Infectious Disease Hospital, Zhengzhou, China
Junhong Hu: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Guixian Wang: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Weitang Yuan: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Xinwei Han: Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Xinwei Han: Interventional Institute of Zhengzhou University, Zhengzhou, China
Lifeng Li: Internet Medical and System Applications of National Engineering Laboratory, Zhengzhou, China
Zhenqiang Sun: Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Zhenqiang Sun: Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China

DOI: https://doi.org/10.3389/fonc.2021.743703
Journal volume & issue: Vol. 11

Abstract

Read online

Colorectal cancer (CRC), a seriously threat that endangers public health, has a striking tendency to relapse and metastasize. Redox-related signaling pathways have recently been extensively studied in cancers. However, the study and potential role of redox in CRC remain unelucidated. We developed and validated a risk model for prognosis and recurrence prediction in CRC patients via identifying gene signatures driven by redox-related signaling pathways. The redox-driven prognostic signature (RDPS) was demonstrated to be an independent risk factor for patient survival (including OS and RFS) in four public cohorts and one clinical in-house cohort. Additionally, there was an intimate association between the risk score and tumor immune infiltration, with higher risk score accompanied with less immune cell infiltration. In this study, we used redox-related factors as an entry point, which may provide a broader perspective for prognosis prediction in CRC and have the potential to provide more promising evidence for immunotherapy.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

Keywords