Frontiers in Endocrinology (Oct 2024)
Obesity and leptin in breast cancer angiogenesis
- Courtney B. Lagarde,
- Courtney B. Lagarde,
- Kapil Thapa,
- Nicole M. Cullen,
- Nicole M. Cullen,
- Mackenzie L. Hawes,
- Mackenzie L. Hawes,
- Khudeja Salim,
- Khudeja Salim,
- Megan C. Benz,
- Megan C. Benz,
- Sophie R. Dietrich,
- Sophie R. Dietrich,
- Sophie R. Dietrich,
- Brandon E. Burow,
- Bruce A. Bunnell,
- Elizabeth C. Martin,
- Elizabeth C. Martin,
- Bridgette M. Collins-Burow,
- Bridgette M. Collins-Burow,
- Ronald M. Lynch,
- Van T. Hoang,
- Van T. Hoang,
- Matthew E. Burow,
- Matthew E. Burow,
- Matthew E. Burow,
- Matthew E. Burow,
- Jennifer S. Fang,
- Jennifer S. Fang
Affiliations
- Courtney B. Lagarde
- Department of Medicine, Section of Hematology and Oncology, Tulane University School of Medicine, New Orleans, LA, United States
- Courtney B. Lagarde
- Tulane University Cancer Center, New Orleans, LA, United States
- Kapil Thapa
- Department of Cell and Molecular Biology, Tulane University School of Science and Engineering, New Orleans, LA, United States
- Nicole M. Cullen
- Department of Medicine, Section of Hematology and Oncology, Tulane University School of Medicine, New Orleans, LA, United States
- Nicole M. Cullen
- Tulane University Cancer Center, New Orleans, LA, United States
- Mackenzie L. Hawes
- Department of Medicine, Section of Hematology and Oncology, Tulane University School of Medicine, New Orleans, LA, United States
- Mackenzie L. Hawes
- Tulane University Cancer Center, New Orleans, LA, United States
- Khudeja Salim
- Department of Medicine, Section of Hematology and Oncology, Tulane University School of Medicine, New Orleans, LA, United States
- Khudeja Salim
- Tulane University Cancer Center, New Orleans, LA, United States
- Megan C. Benz
- Department of Medicine, Section of Hematology and Oncology, Tulane University School of Medicine, New Orleans, LA, United States
- Megan C. Benz
- Tulane University Cancer Center, New Orleans, LA, United States
- Sophie R. Dietrich
- Department of Medicine, Section of Hematology and Oncology, Tulane University School of Medicine, New Orleans, LA, United States
- Sophie R. Dietrich
- Tulane University Cancer Center, New Orleans, LA, United States
- Sophie R. Dietrich
- United States Department of Agriculture Southern Regional Research Center, New Orleans, LA, United States
- Brandon E. Burow
- Department of Cell and Molecular Biology, Tulane University School of Science and Engineering, New Orleans, LA, United States
- Bruce A. Bunnell
- Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, TX, United States
- Elizabeth C. Martin
- Department of Medicine, Section of Hematology and Oncology, Tulane University School of Medicine, New Orleans, LA, United States
- Elizabeth C. Martin
- Tulane University Cancer Center, New Orleans, LA, United States
- Bridgette M. Collins-Burow
- Department of Medicine, Section of Hematology and Oncology, Tulane University School of Medicine, New Orleans, LA, United States
- Bridgette M. Collins-Burow
- Tulane University Cancer Center, New Orleans, LA, United States
- Ronald M. Lynch
- Department of Physiology, College of Medicine, University of Arizona, Tucson, AZ, United States
- Van T. Hoang
- Department of Medicine, Section of Hematology and Oncology, Tulane University School of Medicine, New Orleans, LA, United States
- Van T. Hoang
- Tulane University Cancer Center, New Orleans, LA, United States
- Matthew E. Burow
- Department of Medicine, Section of Hematology and Oncology, Tulane University School of Medicine, New Orleans, LA, United States
- Matthew E. Burow
- Tulane University Cancer Center, New Orleans, LA, United States
- Matthew E. Burow
- Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, United States
- Matthew E. Burow
- Department of Surgery, Tulane University School of Medicine, New Orleans, LA, United States
- Jennifer S. Fang
- Department of Cell and Molecular Biology, Tulane University School of Science and Engineering, New Orleans, LA, United States
- Jennifer S. Fang
- Department of Physiology, Tulane University School of Medicine, New Orleans, LA, United States
- DOI
- https://doi.org/10.3389/fendo.2024.1465727
- Journal volume & issue
-
Vol. 15
Abstract
At the time of breast cancer diagnosis, most patients meet the diagnostic criteria to be classified as obese or overweight. This can significantly impact patient outcome: breast cancer patients with obesity (body mass index > 30) have a poorer prognosis compared to patients with a lean BMI. Obesity is associated with hyperleptinemia, and leptin is a well-established driver of metastasis in breast cancer. However, the effect of hyperleptinemia on angiogenesis in breast cancer is less well-known. Angiogenesis is an important process in breast cancer because it is essential for tumor growth beyond 1mm3 in size as well as cancer cell circulation and metastasis. This review investigates the role of leptin in regulating angiogenesis, specifically within the context of breast cancer and the associated tumor microenvironment in obese patients.
Keywords
